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Diisopropylfluorophosphate

Catalog No. D0879 Name Sigma Aldrich
CAS Number 55-91-4 Website http://www.sigmaaldrich.com
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Storage Chembase ID: 559

SYNONYMS

Title
氟磷酸二异丙酯
IUPAC name
bis(propan-2-yl) fluorophosphonate
IUPAC Traditional name
isoflurophate
Synonyms
DFP
二异丙基氟磷酸酯
DIFP
氟代磷酸二异丙酯

DATABASE IDS

CAS Number 55-91-4
PubChem SID 24893303
MDL Number MFCD00008873
EC Number 200-247-6
Beilstein Number 1723307

PROPERTIES

Gene Information human ... PTGS1(5742), PTGS2(5743)
Boiling Point 62 °C/9 mmHg(lit.)
Density 1.06 g/mL at 25 °C(lit.)
Melting Point -82 °C(lit.)
Refractive Index n20/D 1.385(lit.)
Solubility anhydrous isopropanol: soluble0.1-0.5 M (stable for months if stored at -70 °C)
Solubility H2O: soluble1.5% at 25 °C (very unstable (at pH 7.5, half-life = 1 hr); decomposed by alkali.)
Vapor Pressure 0.58 mmHg ( 20 °C)
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H300 +H310 + H330
European Hazard Symbols Highly toxic Highly toxic (T+)
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Precautionary statements P260-P264-P280-P284-P301 + P310-P302 + P350
RID/ADR UN 3382 6.1/PG 1
Risk Statements 26/27/28
RTECS TE5075000
Safety Statements 36/37/39-45
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 3382
Packing Group 1
German water hazard class 3

DETAILS

Description (简体中文)
Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Stored properly at 2-8°C, in an unopened bottle, DIFP should be stable for a minimum of two years. DIFPis unstable when exposed to moisture. DIFP will develop a dark yellow color upon decomposition.
Biochem/physiol Actions
丝氨酸蛋白酶(如胰蛋白酶和胰凝乳蛋白酶)和乙酰胆碱酯酶的强效抑制剂;还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。

REFERENCES