Diisopropylfluorophosphate

• Catalog No.: D0879
• CAS Number: 55-91-4
• M. F.: C6H14FO3P
• M. W.: 184.1457242

SYNONYMS

• Title: 氟磷酸二异丙酯
• IUPAC name: bis(propan-2-yl) fluorophosphonate
• IUPAC Traditional name: isoflurophate
• Synonyms: DFP; 二异丙基氟磷酸酯; DIFP; 氟代磷酸二异丙酯

DATABASE IDS

• CAS Number: 55-91-4
• PubChem SID: 24893303
• MDL Number: MFCD00008873
• EC Number: 200-247-6
• Beilstein Number: 1723307

PROPERTIES

• Gene Information: human ... PTGS1(5742), PTGS2(5743)
• Boiling Point: 62 °C/9 mmHg(lit.)
• Density: 1.06 g/mL at 25 °C(lit.)
• Melting Point: -82 °C(lit.)
• Refractive Index: n20/D 1.385(lit.)
• Solubility: anhydrous isopropanol: soluble0.1-0.5 M (stable for months if stored at -70 °C)
• Solubility: H2O: soluble1.5% at 25 °C (very unstable (at pH 7.5, half-life = 1 hr); decomposed by alkali.)
• Vapor Pressure: 0.58 mmHg ( 20 °C)
• GHS Signal Word: Danger
• GHS Hazard statements: H300 +H310 + H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3382 6.1/PG 1
• Risk Statements: 26/27/28
• RTECS: TE5075000
• Safety Statements: 36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3382
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (简体中文)

Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Stored properly at 2-8°C, in an unopened bottle, DIFP should be stable for a minimum of two years. DIFPis unstable when exposed to moisture. DIFP will develop a dark yellow color upon decomposition.
Biochem/physiol Actions
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。