Ajmaline

• Catalog No.: A7252
• CAS Number: 4360-12-7
• M. F.: C20H26N2O2
• M. W.: 326.43264

SYNONYMS

• Title: 阿义马林
• IUPAC name: (9R)-13-ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.0^1,^9.0^2,^7.0^1^0,^1^5.0^1^2,^1^7]nonadeca-2,4,6-triene-14,18-diol
• IUPAC Traditional name: (9R)-13-ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.0^1,^9.0^2,^7.0^1^0,^1^5.0^1^2,^1^7]nonadeca-2,4,6-triene-14,18-diol

DATABASE IDS

• CAS Number: 4360-12-7
• MDL Number: MFCD00135652
• EC Number: 224-439-4

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• RTECS: AX8050000
• Safety Statements: 36
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
源自 Rauwolfia serpentina 的吲哚生物碱，是 Ia 类抗心率失常化合物。它阻断骨肌和心肌中的钠离子通道以及处于打开状态（而非闭合状态）的心脏 HERG 钾离子通道。静脉注入阿玛灵可延长心脏的房室 (AV) 传导次数，已经在诊断上用于检测 AV 阻断和其他心脏异常问题。