Adrenocorticotropic Hormone Fragment 4-10 human, rat

• Catalog No.: A0401
• CAS Number: 4037-01-8
• M. F.: C44H59N13O10S
• M. W.: 962.08536
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 4-[2-amino-4-(methylsulfanyl)butanamido]-4-({1-[(1-{[4-carbamimidamido-1-({1-[(carboxymethyl)carbamoyl]-2-(1H-indol-3-yl)ethyl}carbamoyl)butyl]carbamoyl}-2-phenylethyl)carbamoyl]-2-(1H-imidazol-5-yl)ethyl}carbamoyl)butanoic acid
• IUPAC Traditional name: 4-[2-amino-4-(methylsulfanyl)butanamido]-4-{[1-({1-[(4-carbamimidamido-1-{[1-(carboxymethylcarbamoyl)-2-(1H-indol-3-yl)ethyl]carbamoyl}butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-(3H-imidazol-4-yl)ethyl]carbamoyl}butanoic acid
• Synonyms: ACTH4-10

DATABASE IDS

• CAS Number: 4037-01-8
• PubChem SID: 24890423
• MDL Number: MFCD00167482

PROPERTIES

• Purity: ≥97% (HPLC)
• Gene Information: human ... POMC(5443)rat ... Crhr2(64680)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Met-Glu-His-Phe-Arg-Trp-Gly
Other Notes
Core fragment of ACTH, α- and β-MSH, and β-lipotropin
Quality
Lacks adrenocorticotropic activity.
Biochem/physiol Actions
Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.