Cefamandole sodium salt

• Catalog No.: C7145
• CAS Number: 30034-03-8
• M. F.: C18H17N6NaO5S2
• M. W.: 484.48455

SYNONYMS

• IUPAC name: sodium (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• IUPAC Traditional name: sodium cefamandole(1-)

DATABASE IDS

• MDL Number: MFCD07793339
• CAS Number: 30034-03-8
• EC Number: 250-009-0
• PubChem SID: 24892939

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (English)

Application
Cefamandole is used to study antibiotic resistance, the effects of expression and inhibition of penicillin-binding proteins, and the cooperation of antibiotics with host defence mechanisms 1,2.
Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefamandole, a cephalosporin antibiotic, disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. As Cefamandole is broken down in the body, it releases free N-methylthiotetrazole, which can cause hypoprothrombinemia 3.