Homoharringtonine

• Catalog No.: H0635
• CAS Number: 26833-87-4
• M. F.: C29H39NO9
• M. W.: 545.62126

SYNONYMS

• IUPAC name: (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^2,^6.0^6,^1^0.0^1^5,^1^9]icosa-1(20),4,13,15(19)-tetraen-3-yl 1-methyl (3R)-3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate
• IUPAC Traditional name: omacetaxine mepesuccinate

DATABASE IDS

• MDL Number: MFCD03410264
• PubChem SID: 24895407
• CAS Number: 26833-87-4

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 1544 6.1/PG 2
• Risk Statements: 26/27/28
• RTECS: FK0260000
• Safety Statements: 36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Homoharringtonine is a cytotoxic alkaloid from the evergreen tree, Cephalotaxus hainanensis. Binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. Blocks progression of leukemic cells from G1 phase into S phase and from G2 phase into M phase.