(+)-Thalidomide

• Catalog No.: T151
• CAS Number: 2614-06-4
• M. F.: C13H10N2O4
• M. W.: 258.2295
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(3R)-2,6-dioxopiperidin-3-yl]-2,3-dihydro-1H-isoindole-1,3-dione
• IUPAC Traditional name: (R)-thalidomide
• Synonyms: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

DATABASE IDS

• CAS Number: 2614-06-4
• MDL Number: MFCD00210220
• PubChem SID: 24899975

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: human ... LITAF(9516), TNF(7124)mouse ... Nos2(18126)rat ... Nos1(24598)
• Apperance: white solid
• Optical Rotation: [α]23/D +65.5°, c = 2 in DMF(lit.)
• Solubility: DMSO: ≥20 mg/mL
• Solubility: H2O: insoluble
• Solubility: ethanol: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 61-22
• RTECS: TI4925000
• Safety Statements: 53-36/37/39-45
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.