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(+)-Thalidomide

Catalog No. T151 Name Sigma Aldrich
CAS Number 2614-06-4 Website http://www.sigmaaldrich.com
M. F. C13H10N2O4 Telephone 1-800-521-8956
M. W. 258.2295 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 131098

SYNONYMS

IUPAC name
2-[(3R)-2,6-dioxopiperidin-3-yl]-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC Traditional name
(R)-thalidomide
Synonyms
R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

DATABASE IDS

CAS Number 2614-06-4
MDL Number MFCD00210220
PubChem SID 24899975

PROPERTIES

Purity ≥98% (HPLC)
Gene Information human ... LITAF(9516), TNF(7124)mouse ... Nos2(18126)rat ... Nos1(24598)
Apperance white solid
Optical Rotation [α]23/D +65.5°, c = 2 in DMF(lit.)
Solubility DMSO: ≥20 mg/mL
Solubility H2O: insoluble
Solubility ethanol: insoluble
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H302-H360
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 61-22
RTECS TI4925000
Safety Statements 53-36/37/39-45
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

REFERENCES