Picrotoxin

• Catalog No.: P1675
• CAS Number: 124-87-8
• M. F.: C30H34O13
• M. W.: 602.58316

SYNONYMS

• IUPAC name: (1R,3R,5S,8S,9S,12R,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1^9,^1^2.0^3,^5.0^5,^1^3]tetradecane-6,11-dione; (1R,3R,5S,8S,9S,12R,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1^9,^1^2.0^3,^5.0^5,^1^3]tetradecane-6,11-dione
• IUPAC Traditional name: (1R,3R,5S,8S,9S,12R,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1^9,^1^2.0^3,^5.0^5,^1^3]tetradecane-6,11-dione; (1R,3R,5S,8S,9S,12R,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1^9,^1^2.0^3,^5.0^5,^1^3]tetradecane-6,11-dione
• Synonyms: Cocculin

DATABASE IDS

• EC Number: 204-716-6
• Beilstein Number: 3894406
• CAS Number: 124-87-8
• PubChem SID: 24278188
• MDL Number: MFCD00074824

PROPERTIES

• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
• Apperance: white to light yellow powder
• Melting Point: 203 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P301 + P310
• RID/ADR: UN 3462 6.1/PG 2
• Risk Statements: 28
• RTECS: TJ9100000
• Safety Statements: 28-36/37/39-45
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
GABAA receptor antagonist; binds to the GABA receptor-linked Cl- channel.
Other Notes
Molecular complex (1:1) of picrotin and picrotoxinin.