D-Cycloserine

• Catalog No.: C7670
• CAS Number: 68-41-7
• M. F.: C3H6N2O2
• M. W.: 102.09194

SYNONYMS

• Title: D-环丝氨酸
• IUPAC name: (4R)-4-amino-1,2-oxazolidin-3-one
• IUPAC Traditional name: cycloserine
• Synonyms: 4-氨基-3-异噁唑烷酮; (R)-4-氨基-3-异噁唑烷酮

DATABASE IDS

• MDL Number: MFCD00005353
• CAS Number: 68-41-7
• PubChem SID: 24892979
• Beilstein Number: 80798
• EC Number: 200-688-4

PROPERTIES

• Sterility: γ-irradiated
• Apperance: powder
• Melting Point: 147 °C (dec.)(lit.)
• Solubility: 0.1 M phosphate pH 8.0: soluble10 mg/mL (as a stock solution)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: NY2975000
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (简体中文)

Application
分子生物应用建议浓度 100-200μg/mL。
Biochem/physiol Actions
Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.
作用方式：抑制细胞壁的生物合成（D-Ala 肽键的形成）。也会阻碍 D-Ala 向 L-Ala 的转化。抑菌。 抗性机理：干扰 D-Ala 转运。
Reconstitution
直接用小瓶配制推荐范围内任意浓度的储备液。在溶液中不稳定；配制后立即使用。
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information