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Apigenin

Catalog No. A281 Name Sigma Aldrich
CAS Number 520-36-5 Website http://www.sigmaaldrich.com
M. F. C15H10O5 Telephone 1-800-521-8956
M. W. 270.2369 Fax
Purity Email
Storage Chembase ID: 5003

SYNONYMS

IUPAC name
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
IUPAC Traditional name
chamomile
Synonyms
4′,5,7-Trihydroxyflavone

DATABASE IDS

EC Number 208-292-3
CAS Number 520-36-5
Beilstein Number 262620
MDL Number MFCD00006831

PROPERTIES

Apperance yellow to green
Melting Point >300 °C(lit.)
Solubility DMSO: soluble27 mg/mL
Solubility H2O: insoluble
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
RTECS LK9276000
Safety Statements 26-36
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

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