Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)

• Catalog No.: E3257
• CAS Number: 70539-42-3
• M. F.: C18H20N2O12
• M. W.: 456.3576

SYNONYMS

• IUPAC name: 2,5-dioxopyrrolidin-1-yl 1-[2-({4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutanoyl}oxy)ethyl] butanedioate
• IUPAC Traditional name: 2,5-dioxopyrrolidin-1-yl 1-[2-({4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutanoyl}oxy)ethyl] butanedioate
• Synonyms: EGS; Ethylene glycol bis(succinimidyl succinate); Ethylene glycol disuccinate di(N-succinimidyl) ester; Di(N-succinimidyl) ethylene glycol disuccinate

DATABASE IDS

• CAS Number: 70539-42-3
• MDL Number: MFCD00049057
• Beilstein Number: 9167119
• PubChem SID: 24894501

PROPERTIES

• Apperance: powder
• Solubility: acetic acid: water (1:1): ≤50 mg/mL
• Solubility: DMF: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
A homobifunctional, cleavable cross-linking reagent. Typically, coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.
Features and Benefits
The ethylene glycol linkage is cleavable by hydroxylamine.