N-Ethylmaleimide

• Catalog No.: E3876
• CAS Number: 128-53-0
• M. F.: C6H7NO2
• M. W.: 125.12528
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: N-乙基马来酰亚胺
• IUPAC name: 1-ethyl-2,5-dihydro-1H-pyrrole-2,5-dione
• IUPAC Traditional name: N-ethylmaleimide
• Synonyms: NEM

DATABASE IDS

• CAS Number: 128-53-0
• MDL Number: MFCD00005509
• PubChem SID: 24278420
• Beilstein Number: 112448
• EC Number: 204-892-4

PROPERTIES

• Purity: ≥98% (HPLC)
• Quality Level: PREMIUM
• Gene Information: human ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)
• Apperance: crystalline
• Boiling Point: 210 °C(lit.)
• Flash Point: 73 °C
• Flash Point: 163.4 °F
• Melting Point: 43-46 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H311-H314-H317
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P280-P301 + P310-P305 + P351 + P338-P310
• RID/ADR: UN 2928 6.1/PG 2
• Risk Statements: 21-28-34-43
• RTECS: UX9625000
• Safety Statements: 26-28-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2928
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (简体中文)

Application
用于共价修饰蛋白质的半胱氨酸残基的试剂。
Biochem/physiol Actions
使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。
增强来自交感神经元的原生 M 通道的电流，并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。
Preparation Note
NEM 以 50mg/ml 的浓度溶于乙醇可得到透明的溶液。NEM 可溶于水（在 4ml 水中的溶解量 >50mg）；然而，水溶液却不稳定。水解速率为假一级，并显著依赖于 pH 值。