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Caffeine

Catalog No. C0750 Name Sigma Aldrich
CAS Number 58-08-2 Website http://www.sigmaaldrich.com
M. F. C8H10N4O2 Telephone 1-800-521-8956
M. W. 194.1906 Fax
Purity Email
Storage Chembase ID: 86

SYNONYMS

Title
咖啡因
IUPAC name
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
IUPAC Traditional name
caffeine
Synonyms
1,3,7-三甲基黄嘌呤

DATABASE IDS

CAS Number 58-08-2
EC Number 200-362-1
MDL Number MFCD00005758
PubChem SID 24277682
Beilstein Number 17705

PROPERTIES

Grade ReagentPlus®
Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)mouse ... Adora2b(11541)rat ... Adora1(29290), Adora2a(25369)
Apperance white powder
Melting Point 234-236.5 °C(lit.)
Solubility H2O: soluble15 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RID/ADR UN 1544 6.1/PG 3
Risk Statements 22
RTECS EV6475000
Hazard Class 6.1
UN Number 1544
Packing Group 3
German water hazard class 1

DETAILS

Description (简体中文)
Caution
保持密封。
包装
1 kg in poly bottle
5, 100 g in poly bottle
Biochem/physiol Actions
一种据信是通过腺苷受体和单胺类神经递质发挥作用的中枢神经系统兴奋剂。它为腺苷受体拮抗剂和腺苷3′,5′-环单磷酸 (cAMP) 磷酸二酯酶抑制剂。因此,在用咖啡因处理后,细胞内 cAMP 的水平将升高。据报道,它会影响细胞的钙水平,从而使细胞内的钙离子外流。它会使多种化学物质(例如蛋白酶抑制剂)的细胞周期效应无效,从而防止细胞凋亡;同时,还发现它可以抑制细胞的 DNA 修复机制。
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

REFERENCES