Sirolimus

• Catalog No.: Sirolimus
• CAS Number: 53123-88-9
• M. F.: C51H79NO13
• M. W.: 914.17186

SYNONYMS

• IUPAC name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• IUPAC Traditional name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

DATABASE IDS

• PubChem CID: 5284616
• CHEMBL: 413
• Unique Ingredient Identifier: W36ZG6FT64
• Chemspider ID: 10482078
• KEGG ID: D00753
• CHEBI ID: 9168
• Wikipedia Title: Sirolimus
• ATC CODE: L04AA10
• CAS Number: 53123-88-9
• DrugBank ID: DB00877

PROPERTIES

• Admin Routes: Oral
• Bioavailability: 20%, less after eating food rich in fat
• Excretion: Mostly faecal
• Half Life: 57–63 hours
• Legal Status: Rx-only (US)
• EU Licence: Rapamune
• US Licence: Sirolimus
• Metabolism: Hepatic
• Pregnancy Category: C (US)
• Pregnancy Category: C (Australia)
• Protein Bound: 92%