Amphotericin B

• Catalog No.: Amphotericin_B
• CAS Number: 1397-89-3
• M. F.: C47H73NO17
• M. W.: 924.07902

SYNONYMS

• IUPAC name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• IUPAC Traditional name: amphotericin B
• Brand Name: Fungizone

DATABASE IDS

• PubChem CID: 14956
• DrugBank ID: DB00681
• CHEMBL: 267345
• CAS Number: 1397-89-3
• CHEBI ID: 2682
• Chemspider ID: 10237579
• Wikipedia Title: Amphotericin_B
• ATC CODE: A01AB04
• ATC CODE: A07AA07
• ATC CODE: G01AA03
• ATC CODE: J02AA01
• KEGG ID: D00203

PROPERTIES

• Admin Routes: slow i.v.-infusion only
• Bioavailability: 100% (IV)
• Excretion: 40% found in urine after single cumulated over several days ; biliar excretion also important
• Half Life: initial phase : 24 hours, ; second phase : approx. 15 days
• Legal Status: Rx-only, hospitalization recommended.
• Metabolism: renal
• Pregnancy Category: B (US)