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Tacrolimus

Catalog No. Tacrolimus Name Wikipedia.org
CAS Number 104987-11-3 Website http://www.wikipedia.org/
M. F. C44H69NO12 Telephone
M. W. 804.01816 Fax
Purity Email
Storage Chembase ID: 130465

SYNONYMS

IUPAC name
(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
IUPAC Traditional name
tacrolimus

DATABASE IDS

PubChem CID 6473866
ATC CODE D11AH01
DrugBank ID DB00864
CHEMBL 1200738
ATC CODE L04AD02
Wikipedia Title Tacrolimus
CAS Number 104987-11-3
Unique Ingredient Identifier Y5L2157C4J
Chemspider ID 4976056

PROPERTIES

Admin Routes Topical, oral, iv
Bioavailability 20%, less after eating food rich in fat
Excretion Mostly faecal
Half Life 11.3 h (range 3.5-40.6 h)
Legal Status Rx-only
Metabolism Hepatic CYP3A4
Pregnancy Category C
Protein Bound 75-99%

DETAILS

Description (English)

REFERENCES