Tacrolimus

• Catalog No.: Tacrolimus
• CAS Number: 104987-11-3
• M. F.: C44H69NO12
• M. W.: 804.01816

SYNONYMS

• IUPAC name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: tacrolimus

DATABASE IDS

• PubChem CID: 6473866
• ATC CODE: D11AH01
• DrugBank ID: DB00864
• CHEMBL: 1200738
• ATC CODE: L04AD02
• Wikipedia Title: Tacrolimus
• CAS Number: 104987-11-3
• Unique Ingredient Identifier: Y5L2157C4J
• Chemspider ID: 4976056

PROPERTIES

• Admin Routes: Topical, oral, iv
• Bioavailability: 20%, less after eating food rich in fat
• Excretion: Mostly faecal
• Half Life: 11.3 h (range 3.5-40.6 h)
• Legal Status: Rx-only
• Metabolism: Hepatic CYP3A4
• Pregnancy Category: C
• Protein Bound: 75-99%