Posaconazole

• Catalog No.: Posaconazole
• CAS Number: 171228-49-2
• M. F.: C37H42F2N8O4
• M. W.: 700.7773864

SYNONYMS

• IUPAC name: 4-{4-[4-(4-{[(5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1-[(2S,3S)-2-hydroxypentan-3-yl]-4,5-dihydro-1H-1,2,4-triazol-5-one
• IUPAC Traditional name: posaconazole
• Brand Name: Noxafil
• Synonyms: 4-{4-[4-(4-{[(5''R'')-5-(2,4-difluorophenyl)-5-(1''H''-1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1-[(2''S'',3''S'')-2-hydroxypentan-3-yl]-4,5-dihydro-1''H''-1,2,4-triazol-5-one

DATABASE IDS

• KEGG ID: D02555
• Wikipedia Title: Posaconazole
• Chemspider ID: 130409
• Unique Ingredient Identifier: 6TK1G07BHZ
• DrugBank ID: DB01263
• Medline Plus: a607036
• CAS Number: 171228-49-2
• CHEMBL: 1397
• PubChem CID: 147912
• ATC CODE: J02AC04
• CHEBI ID: 64355

PROPERTIES

• Admin Routes: Oral
• Bioavailability: High
• Excretion: Fecal (77%) and renal (14%)
• Half Life: 16 to 31 hours
• Legal Status: Rx-only (US)
• EU Licence: Noxafil
• US Licence: Posaconazole
• Metabolism: Hepatic glucuronidation
• Pregnancy Category: C (US)
• Pregnancy Category: B3 (Australia)
• Protein Bound: 98 to 99%