Diclofenac

• Catalog No.: Diclofenac
• CAS Number: 15307-86-5
• M. F.: C20H24Cl2N2O3
• M. W.: 411.32216

SYNONYMS

• IUPAC name: 2-(pyrrolidin-1-yl)ethan-1-ol; 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
• IUPAC Traditional name: diclofenac; epolamine
• Brand Name: Aclonac, Cataflam, Voltaren

DATABASE IDS

• IUPHAR ligand ID: 2714
• Unique Ingredient Identifier: 144O8QL0L1
• PubChem CID: 3033
• Medline Plus: a689002
• KEGG ID: D07816
• DrugBank ID: DB00586
• CAS Number: 15307-86-5
• ATC CODE: M02AA15
• ATC CODE: M01AB05
• ATC CODE: S01BC03
• CHEMBL: 139
• ATC CODE: D11AX18
• Chemspider ID: 2925
• Wikipedia Title: Diclofenac
• CHEBI ID: 47381

PROPERTIES

• Admin Routes: oral, rectal, intramuscular, intravenous (renal- and gallstones), topical
• Excretion: biliary, only 1% in urine
• Half Life: 1.2-2 hr (35% of the drug enters enterohepatic recirculation)
• Legal Status: Rx-only most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal and Pakistan due to imminent extinction of local vultures
• Legal Status: P (UK)
• Metabolism: hepatic, no active metabolites exist
• Pregnancy Category: C (1st. and 2nd. trimenon), D (third trimenon)
• Pregnancy Category: C (Australia)
• Protein Bound: more than 99%