Chlorpromazine

• Catalog No.: Chlorpromazine
• CAS Number: 50-53-3
• M. F.: C17H19ClN2S
• M. W.: 318.86416

SYNONYMS

• IUPAC name: [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine
• IUPAC Traditional name: chlorpromazine

DATABASE IDS

• CHEBI ID: 3647
• CAS Number: 50-53-3
• Medline Plus: a682040
• ATC CODE: N05AA01
• DrugBank ID: DB00477
• PubChem CID: 2726
• Unique Ingredient Identifier: U42B7VYA4P
• CHEMBL: 71
• Chemspider ID: 2625
• KEGG ID: D00270
• IUPHAR ligand ID: 83
• Wikipedia Title: Chlorpromazine

PROPERTIES

• Admin Routes: Oral, rectal (suppository), IM, IV infusion
• Bioavailability: Oral, 30 to 50% (interindividual variations 10–70%)
• Excretion: Biliary and renal, as metabolites (only traces of unchanged drug)
• Half Life: 16 to 30 hours. In long term treatment, CPZ induces its own metabolism
• Legal Status: Rx-only
• Metabolism: Hepatic, mostly CYP2D6-mediated
• Pregnancy Category: C—only when benefit for the mother exceeds risk to unborn child