Acarbose

• Catalog No.: DB00284
• CAS Number: 56180-94-0
• M. F.: C25H43NO18
• M. W.: 645.60482

SYNONYMS

• IUPAC name: (2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-{[(1S,4S,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-2,3,4-triol
• IUPAC Traditional name: acarbose
• Brand Name: Precose; Prandase; Glucobay

DATABASE IDS

• PubChem CID: 441184
• CAS Number: 56180-94-0
• PubChem SID: 46508248

PROPERTIES

• Hydrophobicity(logP): -6.8

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: An inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. It is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition. (From Martindale The Extra Pharmacopoeia, 31st ed)
• Indication: For treatment and management of diabetes type II (used in combination therapy as a second or third line agent)
• Pharmacology: Used to reduce blood gluose in patients with type 2 diabetes. Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. Acarbose binds to and inhibits alpha amylase and alpha-gluocside hydrolases. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.
• Affected Organisms: Humans and other mammals
• Absorption: Extremely low bioavailability.
• Half Life: 2 hours
• Elimination: The fraction of acarbose that is absorbed as intact drug is almost completely excreted by the kidneys.
• References: Clissold SP, Edwards C: Acarbose. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs. 1988 Mar;35(3):214-43. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Clissold SP, Edwards C: Acarbose. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs. 1988 Mar;35(3):214-43. Pubmed