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L-Ornithine

Catalog No. DB00129 Name DrugBank
CAS Number 70-26-8 Website http://www.ualberta.ca/
M. F. C5H12N2O2 Telephone (780) 492-3111
M. W. 132.16098 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 15

SYNONYMS

IUPAC name
(2S)-2,5-diaminopentanoic acid
IUPAC Traditional name
L-ornithine
Brand Name
OKG (Nature's Bounty)
Synonyms
2,5-Diaminopentanoate
2,5-Diaminovaleric acid
2,5-Diaminopentanoic acid
Ornithine

DATABASE IDS

PubChem CID 6262
PubChem SID 46505239
CAS Number 70-26-8

PROPERTIES

Hydrophobicity(logP) -3.3
Solubility Appreciable

DETAILS

Description (English)
Item Information
Drug Groups approved; nutraceutical
Description Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is a precursor of citrulline and arginine.
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.
Pharmacology A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function.
Toxicity Oral, rat LD50 = 10000 mg/kg
Affected Organisms
Humans and other mammals
Biotransformation Ornithine undergoes extensive metabolism in the liver to L-arginine, polyamines, and proline, and several other metabolites.
Absorption Absorbed from the small intestine via a sodium-dependent active transport process
External Links
Wikipedia
PDRhealth

REFERENCES