8-Azaguanine

• Catalog No.: DB01667
• CAS Number: 134-58-7
• M. F.: C4H4N6O
• M. W.: 152.11416

SYNONYMS

• IUPAC name: 5-amino-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
• IUPAC Traditional name: @8-azaguanine

DATABASE IDS

• CAS Number: 134-58-7

PROPERTIES

• Hydrophobicity(logP): -0.71 [HANSCH,C ET AL. (1995)]
• Solubility: Insoluble

DETAILS

Description (English)

• Drug Groups: experimental
• Description: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. [PubChem]
• References: Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965). "Synthesis of some 2′-deoxyribosides of 8-azaadenine". Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76. "http://dx.doi.org/10.1016/0003-9861(65)90012-3":http://dx.doi.org/10.1016/0003-9861(65)90012-3; Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965). "Synthesis of some 2′-deoxyribosides of 8-azaadenine". Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76. "http://dx.doi.org/10.1016/0003-9861(65)90012-3":http://dx.doi.org/10.1016/0003-9861(65)90012-3
• Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. Pubmed