Item |
Information |
Drug Groups
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approved |
Description
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A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. [PubChem] |
Indication |
For the management of the manifestations of schizophrenia. |
Pharmacology |
Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. |
Toxicity |
Although there have not been any cases of overdosage reported, the symptoms are likely to be somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, or hyper- or hypothermia. |
Affected Organisms |
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Humans and other mammals |
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Biotransformation |
The metabolism of zuclopenthixol is mainly by sulphoxidation, side chain N-dealkylation and glucuronic acid conjugation. The metabolites are devoid of pharmacological activity. |
Half Life |
20 hours (range 12-28 hours) for the tablet form, 19 days for the depot form. |
Protein Binding |
Approximately 98%. |
References |
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[Link]
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Khalifa AE: Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms. Pharmacol Biochem Behav. 2003 Jul;75(4):755-62.
[Pubmed]
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External Links |
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