Home > Compound List > Product Information
Pipotiazine_Molecular_structure_CAS_39860-99-6)
Click picture or here to close

Pipotiazine

Catalog No. DB01621 Name DrugBank
CAS Number 39860-99-6 Website http://www.ualberta.ca/
M. F. C24H33N3O3S2 Telephone (780) 492-3111
M. W. 475.66712 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1397

SYNONYMS

IUPAC name
10-{3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl}-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
IUPAC Traditional name
pipotiazine
Brand Name
Piportil Depot
Piportil L4
Synonyms
Pipothiazine
Pipotiazina [inn-spanish]
Pipotiazinum [inn-latin]

DATABASE IDS

PubChem SID 46508263
PubChem CID 62867
CAS Number 39860-99-6

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Indication For the maintenance treatment of chronic non-agitated schizophrenic patients.
Pharmacology Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It reduces activity of dopamine receptors in the limbic system. Its 5-HT antagonism helps normalize dopamine activity in the cortical regions.
Toxicity Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Affected Organisms
Humans and other mammals

REFERENCES