Meticillin

• Catalog No.: DB01603
• CAS Number: 61-32-5
• M. F.: C17H20N2O6S
• M. W.: 380.4155

SYNONYMS

• IUPAC name: (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• IUPAC Traditional name: (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• Brand Name: Dimocillin; Metacillin
• Synonyms: Methycillin; (2,6-Dimethoxyphenyl)penicillin; 6-(2,6-Dimethoxybenzamido)penicillanic acid; Meticilina [inn-spanish]; Meticilline [inn-french]; Meticillinum [inn-latin]; Methicillinum; Meticillin

DATABASE IDS

• PubChem SID: 46508973
• CAS Number: 61-32-5
• PubChem CID: 6087

PROPERTIES

• Hydrophobicity(logP): 1.22 [HANSCH,C ET AL. (1995)]

DETAILS

Description (English)

• Drug Groups: approved
• Description: One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. [PubChem]
• Indication: Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.
• Pharmacology: Meticillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.
• Affected Organisms: Enteric bacteria and other eubacteria
• Biotransformation: Hepatic (20-40%).
• Absorption: Not absorbed following oral administration.
• Half Life: 25-60 minutes
• External Links: Wikipedia