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Chloral hydrate

Catalog No. DB01563 Name DrugBank
CAS Number 302-17-0 Website http://www.ualberta.ca/
M. F. C2H3Cl3O2 Telephone (780) 492-3111
M. W. 165.40302 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1347


IUPAC name
IUPAC Traditional name
Brand Name
Aquachloral Supprettes


PubChem SID 46507155
CAS Number 302-17-0
PubChem CID 2707


Hydrophobicity(logP) 0.99 [HANSCH,C ET AL. (1995)]
Solubility 793 mg/mL at 25 oC [YALKOWSKY,SH & HE,Y (2003)]


Description (English)
Item Information
Drug Groups illicit; experimental
Description A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. [PubChem]
Indication Mainly used as a hyponotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
Biotransformation Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.
Absorption Rapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.
Elimination Trichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.
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