Chlorphentermine

• Catalog No.: DB01556
• CAS Number: 461-78-9
• M. F.: C10H14ClN
• M. W.: 183.67786

SYNONYMS

• IUPAC name: 1-(4-chlorophenyl)-2-methylpropan-2-amine
• IUPAC Traditional name: chlorphentermine
• Brand Name: Effox; Apsedon; Clomina; Lucofene; Nilgana; Pre-sate; Teramine; Desopimon; Lucofen; Dezopimon
• Synonyms: 1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride; alpha,alpha-dimethyl-p-chlorophenethylamine; Chlorphentermine hydrochloride; 1-(p-Chlorophenyl)-2-methyl-2-aminopropane; 4-Chloro-alpha,alpha-dimethylphenethylamine; Chlorpentermine; Chlorphenteramine; P-chloro-alpha,alpha-dimethylphenethylamine; P-chlorphentermine hydrochloride; 1-(4-Chlorophenyl)-2-methyl-2-propanamine; 4-Chloro-alpha,alpha-dimethylbenzeneethanamine; Beta-(p-chlorophenyl)-alpha,alpha-dimethylethylamine; Chlorophentermine; Chlorophentermine hydrochloride; Chlorphenterminum [inn-latin]; Chlorphenterminum hydrochloride; Clorfentermina [inn-spanish]

DATABASE IDS

• PubChem CID: 10007
• CAS Number: 461-78-9
• PubChem SID: 46505599

PROPERTIES

• Hydrophobicity(logP): 2.60 [HANSCH,C ET AL. (1995)]

DETAILS

Description (English)

• Drug Groups: illicit; experimental; withdrawn
• Description: A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
• Indication: Used as an appetite suppressant.
• Pharmacology: Chlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
• Absorption: Well absorbed following oral administration.
• Half Life: 40 hours
• References: GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. [Pubmed]
• External Links: Wikipedia

REFERENCES

• GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. Pubmed