Ac-Asp-Glu-Val-Asp-paranitroanilide_Molecular_structure_CAS_189950-66-1)

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Ac-Asp-Glu-Val-Asp-paranitroanilide
Catalog No.	03PNA138	Name	MP Biomedicals
CAS Number	189950-66-1	Website	http://www.mpbio.com
M. F.	C26H34N6O13	Telephone
M. W.	638.58056	Fax
Purity		Email
Storage		Chembase ID: 106630

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SYNONYMS

IUPAC name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-[(4-nitrophenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

IUPAC Traditional name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-[(4-nitrophenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

Synonyms

Ac-D-E-V-D-PNA

Ac-Asp-Glu-Val-Asp-PNA

DATABASE IDS

CAS Number

189950-66-1

PROPERTIES

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MSDS Link	Download

DETAILS

Description (English)

A colorimetric substrate for caspase-3 (Km = 9.7 μM), CCP-32 and related cysteine proteases. Sequence is based on the P1-P4 tetrapeptide cleavage site of poly(ADP-ribose) polymerase (PARP) and includes Asp216. Caspase-3 is the protease responsible for the cleavage of PARP. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10. Cleavage of pNA is monitored colorimetrically at ~405 nm.

REFERENCES

Thornberry, N.A. et al., Science, 281:1312 (1998).
Nicholson, D.W. et al., Nature, 376:37 (1995).
Cardone, M.H., et al. 1998. Science 282, 1318.
Lazebnik, Y.A., et al. 1994. Nature 371, 346.