Ac-Tyr-Val-Ala-Asp-paranitroanilide_Molecular_structure_CAS_)

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Ac-Tyr-Val-Ala-Asp-paranitroanilide
Catalog No.	03PNA120	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C29H36N6O10	Telephone
M. W.	628.63034	Fax
Purity		Email
Storage		Chembase ID: 106629

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SYNONYMS

IUPAC name

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-nitrophenyl)carbamoyl]propanoic acid

IUPAC Traditional name

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-nitrophenyl)carbamoyl]propanoic acid

Synonyms

Ac-Tyr-Val-Ala-Asp-PNA

Ac-Y-V-A-D-PNA

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A colorimetric substrate for Caspase-1. Sequence is based on the caspase-1 cleavage site of the IL-1b precursor and includes Asp116. Also a substrate for caspase-4. Cleavage of pNA is monitored colorimetrically at ~405 nm (e = 9,160 M^-1cm^-1).

REFERENCES

Marcelli, M. et al., Cancer Res., 58:76 (1998).
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.