An broad spectrum Caspase inhibitor for in vivo research. The novel Q-VD-OPH compound synthesized using proprietary technology is an irreversible caspase inhibitor specifically designed for in-vivo research.
The Q-VD-OPH irreversibily binds to activated Caspases to block apoptosis. Apoptosis is a physiological for of cell death, which plays important role in embryogenesis, cellular homoestasis, tissue atrophy , and removal damaged and mutated cells. Caspases, which acts as molecular chainsaw are the central components of apoptosis response. Caspases are Cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important role in apoptosis.
The OPH trap with its superior potency, proven cell permeability and minimal toxicity provides an exceptional alternative to the Fluoromethylketone family of inhibitors.
Caserta, T. M.; et al. Apoptosis, 2003, 8, 345-352.
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