Quinoline-Ala-Glu(OMe)-Val-Asp(OMe)-Difluorophenoxymethylketone

• Catalog No.: 03OPH033
• M. F.: C36H41F2N5O10
• M. W.: 741.7350464

SYNONYMS

• IUPAC name: methyl (3S)-5-(2,6-difluorophenoxy)-3-[(2S)-2-[(2S)-5-methoxy-5-oxo-2-[(2S)-2-(quinolin-2-ylformamido)propanamido]pentanamido]-3-methylbutanamido]-4-oxopentanoate
• IUPAC Traditional name: methyl (3S)-5-(2,6-difluorophenoxy)-3-[(2S)-2-[(2S)-5-methoxy-5-oxo-2-[(2S)-2-(quinolin-2-ylformamido)propanamido]pentanamido]-3-methylbutanamido]-4-oxopentanoate
• Synonyms: Q-AE(OMe)VD(OMe)-OPH; Q-Ala-Glu(OMe)-Val-Asp(OMe)-OPH

DETAILS

Description (English)

A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspase-6, caspase-8, caspase-9, and caspase-10), although more effective towards caspases-6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.