Z-Leu-Glu(OMe)-Thr-Asp(OMe)-Fluoromethylketone_Molecular_structure_CAS_)

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Z-Leu-Glu(OMe)-Thr-Asp(OMe)-Fluoromethylketone
Catalog No.	03FK023	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C30H43FN4O11	Telephone
M. W.	654.6810232	Fax
Purity		Email
Storage		Chembase ID: 106517

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SYNONYMS

IUPAC name

methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate

IUPAC Traditional name

methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate

Synonyms

Z-Leu-Glu(OMe)-Thr-Asp(OMe)-FMK

Z-LE(OMe)TD(OMe)-FMK

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

An inhibitor for Caspase-8.

REFERENCES

Nicholson, D.W., and Thornberry, N.A., Caspases:killer proteases. Trends. Biochem. Sci., 22, 299(1997).
Cohen, G.M., Caspases: the executioners ofapoptosis. Biochem. J., 326, 1 (1997).
Fernandes-Alnemri, T., et al., In vitro activation ofCPP32 and Mch3 by Mch4, a novel humanapoptotic cysteine protease containing two FADDlikedomains. Proc. Natl. Acad. Sci. USA, 93, 7464-7469 (1996).
Srinivasula, S.M., et al., Molecular ordering of theFas-apoptotic pathway: the Fas/APO-1 proteaseMch5 is a CrmA-inhibitable protease that activatesmultiple Ced-3/ICE-like cysteine proteases. ProcNatl Acad Sci USA, 93, 14486-14491 (1996).
Thornberry, N. et al., Science, 281:1312 (1998).