Z-Leu-Glu(OMe)-His-Asp(OMe)-Fluoromethylketone_Molecular_structure_CAS_)

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Z-Leu-Glu(OMe)-His-Asp(OMe)-Fluoromethylketone
Catalog No.	03FK022	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C32H43FN6O10	Telephone
M. W.	690.7164232	Fax
Purity		Email
Storage		Chembase ID: 106516

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SYNONYMS

IUPAC name

methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-(1H-imidazol-4-yl)propanamido]-5-fluoro-4-oxopentanoate

IUPAC Traditional name

methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-(1H-imidazol-4-yl)propanamido]-5-fluoro-4-oxopentanoate

Synonyms

Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK

Z-LE(OMe)HD(OMe)-FMK

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

REFERENCES

Gamen, S. et al., Exp. Cell. Res., 258(1):223 (2000).
Fadeel, B., et al. 1999. Leukemia 13, 719.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.