Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone_Molecular_structure_CAS_)

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Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone
Catalog No.	03FK019	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C38H60FN7O13S	Telephone
M. W.	873.9855032	Fax
Purity		Email
Storage		Chembase ID: 106513

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SYNONYMS

IUPAC name

methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}hexanamido)-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate

IUPAC Traditional name

methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamido}hexanamido)-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate

Synonyms

Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK

Biotin-D(OMe)E(OMe)VD(OMe)-FMK

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

An inhibitor/probe for Caspases-3. A biotinylated derivative of Caspase-3 inhibitor Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK (Cat. No. FK010) that has been esterified to increase cell permeability. Also inhibits caspase-6, caspase-7, and caspase-10. Can be used to purify caspase-3 from cell lysates. The addition of esterase will enhance inhibitory activity in cell-free systems.

REFERENCES

Chandler, J. et al., J. Biol. Chem., 273(18):10815 (1998).
Nicholson, D.W. et al., Nature, 376:37 (1995).