Z-Ile-Glu(OMe)-Thr-Asp(OMe)-Fluoromethylketone_Molecular_structure_CAS_)

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Z-Ile-Glu(OMe)-Thr-Asp(OMe)-Fluoromethylketone
Catalog No.	03FK012	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C30H43FN4O11	Telephone
M. W.	654.6810232	Fax
Purity		Email
Storage		Chembase ID: 106506

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SYNONYMS

IUPAC name

methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate

IUPAC Traditional name

methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate

Synonyms

Z-IE(OMe)TD(OMe)-FMK

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

REFERENCES

Zhuang, S. et al., Exp. Cell. Res., 250(1):203 (1999).