Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone_Molecular_structure_CAS_)

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Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone
Catalog No.	03FK010	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C30H41FN4O13	Telephone
M. W.	684.6639432	Fax
Purity		Email
Storage		Chembase ID: 106504

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SYNONYMS

IUPAC name

1-fluoromethyl 4-methyl (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]butanedioate

IUPAC Traditional name

1-fluoromethyl 4-methyl (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]butanedioate

Synonyms

Z-D(OMe)E(OMe)VD(OMe)-FMK

Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

REFERENCES

Chandler, J.M. et al., J. Biol. Chem., 273(18):10815 (1998).
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.