Ac-Ile-Glu-Pro-Asp-7-Amino-4-Methylcoumarin_Molecular_structure_CAS_)

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Ac-Ile-Glu-Pro-Asp-7-Amino-4-Methylcoumarin
Catalog No.	03AMC153	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C32H41N5O11	Telephone
M. W.	671.69484	Fax
Purity		Email
Storage		Chembase ID: 106447

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SYNONYMS

IUPAC name

(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid

IUPAC Traditional name

(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-methyl-2-oxochromen-7-yl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid

Synonyms

Ac-IEPD-AMC

Ac-Ile-Glu-Pro-Asp-AMC

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A fluorogenic substrate for Granzyme B (kcat/Km = 3,330 M^-1s^-1) that also recognizes granzyme B variants (kcat/Km = 55 M^-1s^-1 for R192A and kcat/Km = 8.8 M^-1s^-1 for R192E).
Excitation max.: 360 - 380 nm, Emission max.: 430 - 460 nm

REFERENCES

Harris, J.L. et al., J. Biol. Chem., 273:27364 (1998).
Thornberry, N.A. et al., Science, 281:1312 (1998).