Ac-Asp-Glu-Val-Asp-7-Amino-4-Methylcoumarin_Molecular_structure_CAS_169332-61-0)

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Ac-Asp-Glu-Val-Asp-7-Amino-4-Methylcoumarin
Catalog No.	03AMC138	Name	MP Biomedicals
CAS Number	169332-61-0	Website	http://www.mpbio.com
M. F.	C30H37N5O13	Telephone
M. W.	675.64048	Fax
Purity		Email
Storage		Chembase ID: 106441

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SYNONYMS

IUPAC name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

IUPAC Traditional name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-[(4-methyl-2-oxochromen-7-yl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

Synonyms

Ac-DEVD-AMC

Ac-Asp-Glu-Val-Asp-AMC

DATABASE IDS

CAS Number

169332-61-0

PROPERTIES

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DETAILS

Description (English)

A fluorogenic substrate for Caspase-3 (CPP32, YAMA). Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 μM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
Excitation max.: 365-380 nm, Emission max.: 430-460 nm

REFERENCES

Thornberry, N.A. et al., Science, 281:1312 (1998).
Nicholson, D.W. et al., Nature, 376:37 (1995).
Hermission, M., et al. 2000. Oncogene 19, 2338.