Ac-Tyr-Val-Ala-Asp-7-Amino-4-Methylcoumarin_Molecular_structure_CAS_149231-65-2)

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Ac-Tyr-Val-Ala-Asp-7-Amino-4-Methylcoumarin
Catalog No.	03AMC120	Name	MP Biomedicals
CAS Number	149231-65-2	Website	http://www.mpbio.com
M. F.	C33H39N5O10	Telephone
M. W.	665.69026	Fax
Purity		Email
Storage		Chembase ID: 106435

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SYNONYMS

IUPAC name

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]propanoic acid

IUPAC Traditional name

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-methyl-2-oxochromen-7-yl)carbamoyl]propanoic acid

Synonyms

Ac-YVAD-AMC

Ac-Tyr-Val-Ala-Asp-AMC

DATABASE IDS

CAS Number

149231-65-2

PROPERTIES

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MSDS Link	Download

DETAILS

Description (English)

A fluorogenic substrate for Caspase-1 (ICE). (Km = 8 μM for human recombinant caspase-1). Also a substrate for caspase-4.

REFERENCES

Marcelli, M. et al., Cancer Res., 58:76 (1998).
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Thornberry, N.A., et al. 1992. Nature 356, 768.