Ac-Trp-Glu-His-Asp-7-Amino-4-trifluoromethylcoumarin_Molecular_structure_CAS_)

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Ac-Trp-Glu-His-Asp-7-Amino-4-trifluoromethylcoumarin
Catalog No.	03AFC156	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C38H37F3N8O11	Telephone
M. W.	838.7425896	Fax
Purity		Email
Storage		Chembase ID: 106359

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SYNONYMS

IUPAC name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}-4-[(2S)-2-acetamido-3-(1H-indol-3-yl)propanamido]butanoic acid

IUPAC Traditional name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}-4-[(2S)-2-acetamido-3-(1H-indol-3-yl)propanamido]butanoic acid

Synonyms

Ac-WEHD-AFC

Ac-Trp-Glu-His-Asp-AFC

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A fluorogenic substrate for caspase-5 (ICErel-III, TY), caspase-1, and caspase-4. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Excitation max.: ~400 nm, Emission max.: ~505 nm

REFERENCES

Thornberry, N.A. et al., J. Biol. Chem., 272:17907 (1997).
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.