Ac-Leu-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin_Molecular_structure_CAS_)

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Ac-Leu-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin
Catalog No.	03AFC155	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C32H40F3N5O11	Telephone
M. W.	727.6821096	Fax
Purity		Email
Storage		Chembase ID: 106358

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SYNONYMS

IUPAC name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-2-acetamido-4-methylpentanamido]butanoic acid

IUPAC Traditional name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-2-acetamido-4-methylpentanamido]butanoic acid

Synonyms

Ac-Leu-Glu-Val-Asp-AFC

Ac-LEVD-AFC

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A fluorogenic substrate for Caspase-4 (ICErel-II, TX, ICH-2). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also serves as a substrate for caspase-1.
Excitation max.: ~400 nm, Emission max.: ~505 nm

REFERENCES

Thornberry, N.A. et al., Science, 281:1312 (1998).
Talanian, R.V. et al., J. Biol. Chem., 272:9677 (1997).
Lynch, T., et al. 1997. Mol. Psychiatr. 2, 227.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.