Ac-Leu-Glu-His-Asp-7-Amino-4-trifluoromethylcoumarin_Molecular_structure_CAS_)

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Ac-Leu-Glu-His-Asp-7-Amino-4-trifluoromethylcoumarin
Catalog No.	03AFC154	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C33H38F3N7O11	Telephone
M. W.	765.6903296	Fax
Purity		Email
Storage		Chembase ID: 106357

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SYNONYMS

IUPAC name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}-4-[(2S)-2-acetamido-4-methylpentanamido]butanoic acid

IUPAC Traditional name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}-4-[(2S)-2-acetamido-4-methylpentanamido]butanoic acid

Synonyms

Ac-LEHD-AFC

Ac-Leu-Glu-His-Asp-AFC

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A fluorogenic substrate for Caspase-9 (ICE-LAP6, Mch6). May also act as a substrate for caspase-4 and caspase-5. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Excitation max.: ~400 nm, Emission max.: ~505 nm

REFERENCES

Ito, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
Thornberry, N.A. et al., Science, 281:1312 (1998).
Thornberry, N.A. et al., J. Biol. Chem., 272:17907 (1997).