Ac-Asp-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin_Molecular_structure_CAS_)

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Ac-Asp-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin
Catalog No.	03AFC138	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C30H34F3N5O13	Telephone
M. W.	729.6118696	Fax
Purity		Email
Storage		Chembase ID: 106349

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SYNONYMS

IUPAC name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

IUPAC Traditional name

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

Synonyms

Ac-DEVD-AFC

Ac-Asp-Glu-Val-Asp-AFC

DATABASE IDS

PROPERTIES

Certificate of Analysis	Download
MSDS Link	Download

DETAILS

Description (English)

A fluorogenic substrate for Caspase-3 (CPP32, YAMA). Also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10.
Excitation max.: ~400 nm, Emission max.: ~505 nm

REFERENCES

Thornberry, N.A. et al., Science, 281:1312 (1998).
Nicholson, D.W. et al., Nature, 376:37 (1995).
Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.