Ac-Tyr-Val-Ala-Asp-7-Amino-4-trifluoromethylcoumarin_Molecular_structure_CAS_)

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Ac-Tyr-Val-Ala-Asp-7-Amino-4-trifluoromethylcoumarin
Catalog No.	03AFC120	Name	MP Biomedicals
CAS Number		Website	http://www.mpbio.com
M. F.	C33H36F3N5O10	Telephone
M. W.	719.6616496	Fax
Purity		Email
Storage		Chembase ID: 106343

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SYNONYMS

IUPAC name

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}propanoic acid

IUPAC Traditional name

(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}propanoic acid

Synonyms

Ac-YVAD-AFC

Ac-Tyr-Val-Ala-Asp-AFC

DATABASE IDS

PROPERTIES

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MSDS Link	Download

DETAILS

Description (English)

A fluorogenic substrate for Caspase-1 (ICE). May also be used as a caspase-3, caspase-4, or caspase-7 substrate. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.

REFERENCES

Marcelli, M. et al., Cancer Res., 58:76 (1998).
Susin, S.A., et al. 1999. J. Exp. Med. 189, 381.
Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.