ITRACONAZOLE

• Catalog No.: 02199872
• CAS Number: 84625-61-6
• M. F.: C35H38Cl2N8O4
• M. W.: 705.63342
• Storage: 2-8°C

SYNONYMS

• IUPAC name: 1-(butan-2-yl)-4-{4-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
• IUPAC Traditional name: @itraconazole
• Synonyms: Oriconazole, R51211, Sporanox

DATABASE IDS

• CAS Number: 84625-61-6

PROPERTIES

• Melting Point: 166.0-168.0°C
• European Hazard Symbols: Irritant (Xi)
• Risk Statements: R:36/37/38
• RTECS: XZ5481000
• Safety Statements: S:22-26-36
• Storage Condition: 2-8°C

REFERENCES

• Chau, A.S., "Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae." Antimicrob. Agents Chemother. 50, 3917-3919, (2006)
• Xiong, Q., et al., "Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors." Antimicrob. Agents Chemother. 49, 518-524, (2005)
• Sabatelli, F., et al., "In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts." Antimicrob. Agents Chemother. 50, 2009-2015, (2006)
• Vanden Bossche, H., et al., "Effects of itraconazole on cytochrome P-450-dependent sterol 14α-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans." Antimicrob. Agents Chemother. 37, 2101-2105, (1993)