PAXILLINE

• Catalog No.: 02193944
• CAS Number: 57186-25-1
• M. F.: C27H33NO4
• M. W.: 435.55522
• Storage: -20°C

SYNONYMS

• IUPAC name: (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0?,??.0?,??.0??,??.0??,??]tetracosa-9,16(24),17,19,21-pentaen-8-one
• IUPAC Traditional name: paxilline

DATABASE IDS

• CAS Number: 57186-25-1

PROPERTIES

• RTECS: DJ2830000
• Storage Condition: -20°C

DETAILS

Description (English)

From Penicillium paxilli
This fungal mycotoxin possess potent excitatory action on acetylcholine release from nerve terminals. It specifically inhibits smooth muscle high conductance Ca^2+ -activated K^+ channels, as well as, enhances [^125 I]-charybotoxin binding to these channels.

REFERENCES

• Knaus, et al., Biochemistry , 33 : 5819 (1994).