DEMECOLCINE

• Catalog No.: 02190195
• CAS Number: 477-30-5
• M. F.: C21H25NO5
• M. W.: 371.4269
• Storage: 2-8°C

SYNONYMS

• IUPAC name: (10S)-3,4,5,14-tetramethoxy-10-(methylamino)tricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2(7),3,5,11,14-hexaen-13-one
• IUPAC Traditional name: colcemid
• Synonyms: N-Methyl-N-Deacetylcolchicine; 6,7-Dihydro-1,2,3,10-Tetramethoxy-7-(Methylamino) Benzo (alpha) Heptalen-9(5H)-one; Colcemid

DATABASE IDS

• EC Number: 207-514-6
• CAS Number: 477-30-5

PROPERTIES

• Melting Point: 186°C
• Australian Hazchem: 2XE
• Emergency Response Guidebook(ERG) Number: 154
• EU Classification: T2
• EU Hazard Identification Number: 6.1B
• European Hazard Symbols: Toxic (T)
• Risk Statements: R:25
• RTECS: GH0800000
• Safety Statements: S:28-36/37/39-45-53
• Storage Condition: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: II

DETAILS

Description (English)

Crystalline
Used to immobilize chromosomes by inactivating the spindle fiber mechanism during metaphase. Binds tubulin and interferes with microtubule-dependent cell functions.

REFERENCES

• Ray, K., et al., Eur. J. Biochem., 142: 577 (1984).