Cathine

• Catalog No.: DB01486
• CAS Number: 492-39-7
• M. F.: C9H13NO
• M. W.: 151.20562

SYNONYMS

• IUPAC name: (1S,2S)-2-amino-1-phenylpropan-1-ol
• IUPAC Traditional name: cathine
• Synonyms: (+)-Norpseudoephedrine; β-hydroxyamphetamine; Pseudonorephedrine; D-Cathine; norpseudoephedrine; (+)-norephedrin; (1S,2R)-(+)-Norephedrine; D-norephedrine; D-phenylpropanolamine; Katine

DATABASE IDS

• PubChem SID: 46509110
• CAS Number: 492-39-7
• PubChem CID: 441457

PROPERTIES

• Hydrophobicity(logP): 0.83 [SANGSTER (1994)]
• Solubility: 20 mg/mL at 25 oC [BEILSTEIN]

DETAILS

Description (English)

• Drug Groups: illicit; experimental
• Description: Cathine (β-hydroxyamphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat). Cathine is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance. [Wikipedia]
• Indication: Used to decrease appetite.
• Pharmacology: Closely related to ephedrine, cathinone and other amphetamines, it may contribute to the stimulant effect of Catha edulis, although another constituent, cathinone appears to show stronger activity.
• Affected Organisms: Humans and other mammals
• Absorption: The mucosa of the oral cavity is considered to be the first absorption segment, where the major proportion of the alkaloids is absorbed (mean +/- SD: 84 +/- 6% for cathine). [PMID: 12848785]
• Half Life: 5.2 +/- 3.4 hours
• References: Toennes SW, Harder S, Schramm M, Niess C, Kauert GF: Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol. 2003 Jul;56(1):125-30. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Toennes SW, Harder S, Schramm M, Niess C, Kauert GF: Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol. 2003 Jul;56(1):125-30. Pubmed