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(±)-EPIBATIDINE_Molecular_structure_CAS_140111-52-0)
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(±)-EPIBATIDINE

Catalog No. 02159918 Name MP Biomedicals
CAS Number 140111-52-0 Website http://www.mpbio.com
M. F. C11H13ClN2 Telephone
M. W. 208.68732 Fax
Purity 99% Email
Storage 0°C, Store Under Nitrogen, Protect from light Chembase ID: 105363

SYNONYMS

IUPAC name
2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
IUPAC Traditional name
epibatidine

DATABASE IDS

CAS Number 140111-52-0

PROPERTIES

Certificate of Analysis Download
Purity 99%
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Risk Statements R:23/24/25
Safety Statements S:22-35-45-36/37/39
Storage Condition 0°C, Store Under Nitrogen, Protect from light

DETAILS

Description (English)
Synthetic Purity: 99% Most potent agonist to the nicotinic acetylcholine receptor known. The natural (+) isomer is 2 fold more potent than the (-) anantiomer with respect to analgesic activity in mice. Both enantiomers bind with high affinity (Ki=0.045 and 0.3058 nM respectively) to rat brain membrane nicotinic receptors.

REFERENCES

  • Spande, T.F., et al., J. Am. Chem. Soc., 114: 3475 (1992).
  • Qian, C., et al., Eur. J. Pharmacol., 250: R13 (1993).
  • Badio, B. and Daly, J.W., Mol. Pharmacol., 45: 563 (1994).