(±)-EPIBATIDINE

• Catalog No.: 02159918
• CAS Number: 140111-52-0
• M. F.: C11H13ClN2
• M. W.: 208.68732
• Purity: 99%
• Storage: 0°C, Store Under Nitrogen, Protect from light

SYNONYMS

• IUPAC name: 2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
• IUPAC Traditional name: epibatidine

DATABASE IDS

• CAS Number: 140111-52-0

PROPERTIES

• Purity: 99%
• European Hazard Symbols: Toxic (T)
• Risk Statements: R:23/24/25
• Safety Statements: S:22-35-45-36/37/39
• Storage Condition: 0°C, Store Under Nitrogen, Protect from light

DETAILS

Description (English)

Synthetic Purity: 99% Most potent agonist to the nicotinic acetylcholine receptor known. The natural (+) isomer is 2 fold more potent than the (-) anantiomer with respect to analgesic activity in mice. Both enantiomers bind with high affinity (Ki=0.045 and 0.3058 nM respectively) to rat brain membrane nicotinic receptors.

REFERENCES

• Spande, T.F., et al., J. Am. Chem. Soc., 114: 3475 (1992).
• Qian, C., et al., Eur. J. Pharmacol., 250: R13 (1993).
• Badio, B. and Daly, J.W., Mol. Pharmacol., 45: 563 (1994).