IBERIOTOXIN

• Catalog No.: 02158935
• CAS Number: 129203-60-7
• M. F.: C179H274N50O55S7
• M. W.: 4230.84786
• Purity: 98%
• Storage: 0°C

SYNONYMS

• IUPAC name: (2R)-4-carbamoyl-2-[(2R)-3-(4-hydroxyphenyl)-2-{[(1S,4R,7S,12S,15S,18S,21S,24S,30S,33S,36S,42S,45R,50S,53S,56S,59S,62S,65S,68R,75S,78S,84S,89R,92R,95S)-15,42,62,75,78-pentakis(4-aminobutyl)-24-benzyl-4,36-bis(3-carbamimidamidopropyl)-50-[(2S)-3-carboxy-2-[(2R)-2-[(2R)-3-carboxy-2-[(2R,3S)-3-hydroxy-2-[(2R)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}-3-phenylpropanamido]butanamido]propanamido]-3-methylbutanamido]propanamido]-65-(2-carboxyethyl)-18,33-bis(carboxymethyl)-53,59,92-tris(hydroxymethyl)-89-(1H-indol-3-ylmethyl)-21-(2-methylpropyl)-84-[2-(methylsulfanyl)ethyl]-2,5,13,16,19,22,25,28,31,34,37,40,43,51,54,57,60,63,66,74,77,80,83,86,87,90,93,96-octacosaoxo-30,56,95-tris(propan-2-yl)-9,10,47,48,70,71-hexathia-3,6,14,17,20,23,26,29,32,35,38,41,44,52,55,58,61,64,67,73,76,79,82,85,88,91,94,97-octacosaazatricyclo[43.27.14.11^{12,68}]heptanonacontan-7-yl]formamido}propanamido]butanoic acid
• IUPAC Traditional name: (2R)-4-carbamoyl-2-[(2R)-3-(4-hydroxyphenyl)-2-{[(1S,4R,7S,12S,15S,18S,21S,24S,30S,33S,36S,42S,45R,50S,53S,56S,59S,62S,65S,68R,75S,78S,84S,89R,92R,95S)-15,42,62,75,78-pentakis(4-aminobutyl)-24-benzyl-4,36-bis(3-carbamimidamidopropyl)-50-[(2S)-3-carboxy-2-[(2R)-2-[(2R)-3-carboxy-2-[(2R,3S)-3-hydroxy-2-[(2R)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}-3-phenylpropanamido]butanamido]propanamido]-3-methylbutanamido]propanamido]-65-(2-carboxyethyl)-18,33-bis(carboxymethyl)-53,59,92-tris(hydroxymethyl)-89-(1H-indol-3-ylmethyl)-30,56,95-triisopropyl-21-(2-methylpropyl)-84-[2-(methylsulfanyl)ethyl]-2,5,13,16,19,22,25,28,31,34,37,40,43,51,54,57,60,63,66,74,77,80,83,86,87,90,93,96-octacosaoxo-9,10,47,48,70,71-hexathia-3,6,14,17,20,23,26,29,32,35,38,41,44,52,55,58,61,64,67,73,76,79,82,85,88,91,94,97-octacosaazatricyclo[43.27.14.11^{12,68}]heptanonacontan-7-yl]formamido}propanamido]butanoic acid
• Synonyms: IBTX (SCORPION, BUTHUS TAMULUS); IBTX; pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln [Disulfide Bridges: 7?28; 13?33; 17?35]

DATABASE IDS

• CAS Number: 129203-60-7

PROPERTIES

• Auto Ignition Point: No data
• Boiling Point: No data
• Density: No data
• Flash Point: No data
• Melting Point: No data
• Partition Coefficient: No data
• Vapor Density: No data
• Vapor Pressure: No data
• Purity: 98%
• Australian Hazchem: 2X
• Emergency Response Guidebook(ERG) Number: 153
• EU Classification: T2
• EU Hazard Identification Number: 6.1B
• European Hazard Symbols: Highly toxic (T+)
• Risk Statements: R:25
• RTECS: NH6107500
• Safety Statements: S:28-36/37/39-45-53
• Storage Condition: 0°C
• Hazard Class: 6.1
• UN Number: 3172
• Packing Group: III

DETAILS

Description (English)

From Buthus tamulus Scorpion
Purity: 98%
More specific than charybdotoxin at inhibiting high conductance Ca2+-activated K+ channel via allosteric inhibition.

REFERENCES

• Galvez, A., et al., J. Biol. Chem., 265: 11083 (1990)
• Essin, K., et al., BK Channels In Innate Immune Functions Of Neutrophils And Macrophages. Blood 113, 1326-31, (2009)
• Galvez, A., Purification and characterization of a unique potent peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 265, 11083, (1990)
• Candia, S. et al., Mode of action of Iberiotoxin, a potent blocker of the large conductance Ca2+-activated K+ channel. Biophys. J. 63, 583-90, (1992)
• Satake, N., et al., The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by β1- and β2-adrenoceptor activation in rat aortic rings. Br. J. Pharmacol. 119, 505, (1996)
• Shao, L.R., et al., The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells. J. Physiol. 521, 135, (1999)
• Merck 14,4874