HERBIMYCIN A

• Catalog No.: 02158928
• CAS Number: 70563-58-5
• M. F.: C30H42N2O9
• M. W.: 574.66248
• Storage: -20°C, Protect from light

SYNONYMS

• IUPAC name: 8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• IUPAC Traditional name: 8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

DATABASE IDS

• CAS Number: 70563-58-5

PROPERTIES

• RTECS: LX8930000
• Storage Condition: -20°C, Protect from light

DETAILS

Description (English)

From Streptomyces hygroscopicus
Irreversibly inhibits tyrosine kinsases. Also, inhibits thrombin-stimulated tyrosine phosphorylation of phospholipase C. Antibiotic against Src, Yes, Fps, Ros, and, Erb oncongene reagents.

REFERENCES

• Satoh, T., et al., J. Biol. Chem. , 267 : 2537, (1992).
• Weiss, R. and Nuccitelli, R., J. Biol. Chem. , 267 : 5608, (1992).
• Uehara, Y. and Fukazawa, H., Methods Enzymol. , 201 : 370, (1991).
• Fukazawa, H., et al., Biochem. Pharmacol. , 42 : 1661, (1991).